Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension:
Objective: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension.
Methods: A retrospective study was carried out with three groups of amniotic fluid samples (15–18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, and 30 normal pregnancy.
Results: A significant difference was observed in myo-inositol concentrations between the median gestational diabetes values (124.0 mmol/L, IQR 90.0–162.5) and the control group values (79.0 mmol/L, IQR 62.0–107.5), but also with gestational hypertension median values (79.0 mmol/ L, IQR 67.75–92.0) (p50.001).
Conclusions: This study has shown that myo-inositol concentrations in amniotic fluid increased significantly in women later developing gestational diabetes compared to the control group.